The Polymodal Receptor - A Gateway to Pathological Pain (Progress in Brain Research)

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Hardcover , pages. More Details Original Title. Friend Reviews. To see what your friends thought of this book, please sign up. To ask other readers questions about The Polymodal Receptor , please sign up. Be the first to ask a question about The Polymodal Receptor. Lists with This Book. This book is not yet featured on Listopia. Community Reviews. Showing Rating details. All Languages. Neuron 54 , — Takashima, Y. Diversity in the neural circuitry of cold sensing revealed by genetic axonal labeling of transient receptor potential melastatin 8 neurons. Chung, M.

Suzuki, M. Localization of mechanosensitive channel TRPV4 in mouse skin. Warm temperatures activate TRPV4 in mouse keratinocytes. Hoffmann, T. Sensory transduction in peripheral nerve axons elicits ectopic action potentials. Hwang, S.


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Vanilloid receptor VR1-positive primary afferents are glutamatergic and contact spinal neurons that co-express neurokinin receptor NK1 and glutamate receptors. Yang, K.

Capsaicin facilitates excitatory but not inhibitory synaptic transmission in substantia gelatinosa of the rat spinal cord. Kosugi, M. Activation of TRPA1 channel facilitates excitatory synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord. Ferrini, F. Vanilloid receptor-1 TRPV1 -dependent activation of inhibitory neurotransmission in spinal substantia gelatinosa neurons of mouse. Pain , — Fischbach, T. Effects of anandamide and noxious heat on intracellular calcium concentration in nociceptive DRG neurons of rats.

Wang, S. Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain. Brain , — Wang, H. Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission. Gibson, H. TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron 57 , — Starowicz, K.

Update on peripheral mechanisms of pain: beyond prostaglandins and cytokines

Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways. Ji, R. Neuron 36 , 57—68 Zhang, X. Documentation of the changes in TRPV1 that contribute to peripheral sensitization. Zhu, W.

Cell Neurosci. Mandadi, S. Lukacs, V. Dual regulation of TRPV1 by phosphoinositides. Kawamata, T. Contribution of transient receptor potential vanilloid subfamily 1 to endothelininduced thermal hyperalgesia. Neuroscience , — Facer, P. BMC Neurol. Lauria, G. Expression of capsaicin receptor immunoreactivity in human peripheral nervous system and in painful neuropathies.

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Culshaw, A. Identification and biological characterization of 6-arylisopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain.


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  • Peripheral and Central Mechanisms of Pain Generation;

Dai, Y. Diogenes, A.

Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli

Obata, K. TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury.

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Grant, A. Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. Alessandri-Haber, N. Hypotonicity induces TRPV4-mediated nociception in rat. Neuron 39 , — Xiao, R. Calcium plays a central role in the sensitization of TRPV3 channel to repetitive stimulations. Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Liu, B. Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5-bisphosphate. Premkumar, L. Downregulation of transient receptor potential melastatin 8 by protein kinase C-mediated dephosphorylation.

Rohacs, T. Andersson, D. Modulation of the cold-activated channel TRPM8 by lysophospholipids and polyunsaturated fatty acids. Vanden Abeele, F. Barton, N. Birder, L. Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Iida, T. Attenuated fever response in mice lacking TRPV1.

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Ciura, S. Transient receptor potential vanilloid 1 is required for intrinsic osmoreception in organum vasculosum lamina terminalis neurons and for normal thirst responses to systemic hyperosmolality. Marsch, R. Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice.

Razavi, R.